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Are you interested in how the brain works? Men needed!

If you take part, we will ask you to: - Provide a cheek swab (to see which form of the gene you have) then, if suitable, come to the lab and: - Take a single dose of a drug or a dummy pill; - Fill in some questionnaires and give samples of saliva; - Complete tasks of mental maths, memory and reward, while in an MRI brain scanner. The study will take one afternoon (around 3.5 hours).

OxCaMS

Have you been experiencing mood swings? Have you recently engaged in risky behaviour, been so hyper that you got into trouble, had much more energy than usual and/or been so irritable that you started fights?

The effect of losartan on fear learning

We are looking for healthy volunteers aged 18-40 years and fluent in English to take part in a study investigating how a single dose of the medication losartan affects learning and information processing, using a simple computer task. Losartan is currently used to treat high blood pressure. However, we think that it may also enhance the effectiveness of psychological therapies such as Cognitive-Behaviour Therapy. The study involves three appointments of about 5 hours in total.

Ebselen as an add-on treatment in hypo/mania

Lithium can stabilise the highs and lows of mood but requires careful monitoring. We are interested in a new lithium-like medicine called ebselen which might help improve recovery from acute hypo/manic episodes. The study involves adding ebselen to your usual medication during an acute episode of hypo/mania.

Neural mechanisms underlying decision making

Who are we looking for? Healthy fluent English-speaking people aged 18-85 who are not pregnant. You will be asked questions about your medical history to check your suitability for an MRI scan. MRI is a method to measure brain activity that allows us to see how the brain is organised, processes information and performs skills like speech or memory. This scan is safe and does not involve any needles or injections.

Friends of Oxford Dementia and Ageing Research (OxDARE)

Anyone who is interested in finding out more about dementia and ageing research in Oxford is invited to become a Friend of OxDARE. Friends can choose to register an interest in taking part in future studies and/or receive quarterly newsletters. When new studies get underway, OxDARE researchers will invite interested Friends to take part by email. If you are contacted by one of our researchers, it is your choice whether you would like to participate in their study or not.

Volunteers needed for Dementia Prevention Study: European Prevention of Alzheimer’s Dementia (EPAD)

The European Prevention of Alzheimer’s Dementia (EPAD study) aims to address the urgent need for new treatments designed to prevent Alzheimer’s Dementia. The main study objectives are to: 1. Learn and understand better the factors involved in developing Alzheimer’s dementia. 2. To develop new treatments more quickly which are hoped to prevent Alzheimer’s dementia.

Healthy volunteers needed for emotional processing study

Volunteers should be right handed, have no history of a psychological disorder such as depression, anxiety, or an eating disorder, no previous participation in a study using computerised tasks with emotional faces, and no participation in a drug study within the last 3 months. Central University Research Ethics Committee number: R57219/RE001

VOLUNTEERS NEEDED FOR MAGNETIC RESONANCE STUDIES OF THE BRAIN

MRI is a type of brain scan that allows us to see how the brain is organised and performs tasks like decision making. The scan is safe and does not involve any needles or injections. Who are we looking for? Fluent English-speaking men or women aged 18-45, who are not pregnant, with a range of symptoms of depression. You will be asked questions about your medical history to check your suitability for an MRI scan.

Daylight Study: Pilot Study of Digital Cognitive Behavioural Therapy for Anxiety

Most people with anxiety struggle with worry and stress. Getting help in person can be challenging for a number of reasons, which is why this study aims to find out whether digital Cognitive Behavioural Therapy (a psychological treatment delivered via a mobile app) can help improve anxiety. The study is suitable for adults aged 18 years and above who have persistent problems with anxiety.

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