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If you are healthy, without a history of a mental health disorder (like depression), fluent English-speaking, not pregnant, and aged 18 to 40 years, we invite you to take part in a study to investigate the effects of a single dose of citalopram (a medication for depression) on the brain's response to faces using the 7T MRI scanner.

If you take part, we will ask you to:

• Complete an online screening questionnaire (15 minutes)

• Attend an in-person screening visit (1.5 hour)

o You will also be asked questions about your medical history to check your suitability for an MRI scan.

• Attend an in-person research visit (5 hours) to take a single dose of the antidepressant citalopram or placebo, and complete simple tasks whilst having a brain scan in a 7T MRI scanner

o MRI scanning allows us to see how the brain is organised, processes information and performs skills like speech or memory.

o This scan is safe and does not involve any needles or injections.

The study takes place at the Department of Psychiatry at the Warneford Hospital, as well as at the Oxford Centre for Functional MRI of the Brain (FMRIB), located at the John Radcliffe Hospital. You will be compensated for your time and reimbursed reasonable travel expenses.

 

Ethics approval reference: R88787/RE003

We are looking for

Healthy volunteers, without a history of a mental health disorder (like depression), fluent English-speaking, not pregnant, and aged 18 to 40 years.

Expenses

You will be compensated for your time and reimbursed reasonable travel expenses.