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We have observed an unexpected 17-fold increase in risk of fatal [corrected] myocardial infarction (relative risk 16.9, 95% confidence interval 3.9-72.8) associated with current use of psychotropic drugs. This incidental finding, in a case-control study of cardiovascular mortality in women aged 16-39 not designed to test any hypothesis about psychotropic drugs, should be treated cautiously. There is, however, evidence of a relation between psychiatric morbidity and cardiovascular disease and the association recorded here requires further investigation.


Journal article



Publication Date





1067 - 1068


Adolescent, Adult, Case-Control Studies, Female, Humans, Myocardial Infarction, Psychotropic Drugs, Risk Factors, Subarachnoid Hemorrhage, Thrombophlebitis, United Kingdom