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Theta and gamma frequency oscillations occur in the same brain regions and interact with each other, a process called cross-frequency coupling. Here, we review evidence for the following hypothesis: that the dual oscillations form a code for representing multiple items in an ordered way. This form of coding has been most clearly demonstrated in the hippocampus, where different spatial information is represented in different gamma subcycles of a theta cycle. Other experiments have tested the functional importance of oscillations and their coupling. These involve correlation of oscillatory properties with memory states, correlation with memory performance, and effects of disrupting oscillations on memory. Recent work suggests that this coding scheme coordinates communication between brain regions and is involved in sensory as well as memory processes.

Original publication

DOI

10.1016/j.neuron.2013.03.007

Type

Journal article

Journal

Neuron

Publication Date

20/03/2013

Volume

77

Pages

1002 - 1016

Keywords

Animals, Brain Waves, Hippocampus, Humans, Memory, Neural Pathways, Theta Rhythm