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The personality traits of neuroticism and extraversion are predictive of a number of social and behavioural outcomes and psychiatric disorders. Twin and family studies have reported moderate heritability estimates for both traits. Few associations have been reported between genetic variants and neuroticism/extraversion, but hardly any have been replicated. Moreover, the ones that have been replicated explain only a small proportion of the heritability (

Original publication




Journal article


Transl Psychiatry

Publication Date





Adolescent, Adult, Aged, Aged, 80 and over, Anxiety Disorders, Character, Child, Cohort Studies, Diseases in Twins, Extraversion, Psychological, Female, Gene-Environment Interaction, Genetic Variation, Genome-Wide Association Study, Humans, Linear Models, Male, Middle Aged, Neuroticism, Phenotype, Polymorphism, Single Nucleotide, Sex Factors