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Associations between Mobility, Cognition, and Brain Structure in Healthy Older Adults.
Mobility limitations lead to a cascade of adverse events in old age, yet the neural and cognitive correlates of mobility performance in older adults remain poorly understood. In a sample of 387 adults (mean age 69.0 ± 5.1 years), we tested the relationship between mobility measures, cognitive assessments, a…
Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study.
Objectives To investigate whether moderate alcohol consumption has a favourable or adverse association or no association with brain structure and function.Design Observational cohort study with weekly alcohol intake and cognitive performance measured repeatedly over 30 years (1985-2015). Multim…
Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults.
Uncoupling protein 2 (UCP2) is a mitochondrial membrane protein that plays a role in uncoupling electron transport from adenosine triphosphate (ATP) formation. Polymorphisms of the UCP2 gene in humans affect protein expression and function and have been linked to survival into old age. Since UCP2 is e…
Distinct resting-state functional connections associated with episodic and visuospatial memory in older adults.
Episodic and spatial memory are commonly impaired in ageing and Alzheimer's disease. Volumetric and task-based functional magnetic resonance imaging (fMRI) studies suggest a preferential involvement of the medial temporal lobe (MTL), particularly the hippocampus, in episodic and spatial memory processi…
Associations between self-reported sleep quality and white matter in community-dwelling older adults: A prospective cohort study.
Both sleep disturbances and decline in white matter microstructure are commonly observed in ageing populations, as well as in age-related psychiatric and neurological illnesses. A relationship between sleep and white matter microstructure may underlie such relationships, but few imaging studies have directly…
Depression is linked to dementia in older adults.
Depression and dementia are both common conditions in older people, and they frequently occur together. Late life depression affects about 3.0-4.5% of adults aged 65 and older. Depression occurs in up to 20% of patients with Alzheimer’s disease and up to 45% of patients with vascular dementia. Rather tha…
The level of cognitive function and recognition of emotions in older adults.
BACKGROUND: The association between cognitive decline and the ability to recognise emotions in interpersonal communication is not well understood. We aimed to investigate the association between cognitive function and the ability to recognise emotions in other people's facial expressions across the full con…
Multimodal brain-age prediction and cardiovascular risk: The Whitehall II MRI sub-study.
Brain age is becoming a widely applied imaging-based biomarker of neural aging and potential proxy for brain integrity and health. We estimated multimodal and modality-specific brain age in the Whitehall II (WHII) MRI cohort using machine learning and imaging-derived measures of gray matter (GM) morpholog…
Prominent health problems, socioeconomic deprivation, and higher brain age in lonely and isolated individuals: A population-based study.
Loneliness is linked to increased risk for Alzheimer's disease, but little is known about factors potentially contributing to adverse brain health in lonely individuals. In this study, we used data from 24,867 UK Biobank participants to investigate risk factors related to loneliness and estimated brain age based o…
No Association Between Loneliness, Episodic Memory and Hippocampal Volume Change in Young and Healthy Older Adults: A Longitudinal European Multicenter Study.
BACKGROUND: Loneliness is most prevalent during adolescence and late life and has been associated with mental health disorders as well as with cognitive decline during aging. Associations between longitudinal measures of loneliness and verbal episodic memory and brain structure should thus be investigated…
People's interest in brain health testing: Findings from an international, online cross-sectional survey.
UNLABELLED: Brain health entails mental wellbeing and cognitive health in the absence of brain disorders. The past decade has seen an explosion of tests, cognitive and biological, to predict various brain conditions, such as Alzheimer's Disease. In line with these current developments, we investigated people's…
Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study.
STUDY OBJECTIVES: To examine the association between sleep duration trajectories over 28 years and measures of cognition, gray matter volume, and white matter microstructure. We hypothesize that consistently meeting sleep guidelines that recommend at least 7 hours of sleep per night will be associated wit…
Association of Diet and Waist-to-Hip Ratio With Brain Connectivity and Memory in Aging.
IMPORTANCE: Epidemiological studies suggest that lifestyle factors are associated with risk of dementia. However, few studies have examined the association of diet and waist to hip ratio (WHR) with hippocampus connectivity and cognitive health. OBJECTIVE: To ascertain how longitudinal changes in diet quality an…