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Dr. Jane Walker, Department of Psychiatry, is the 2018 recipient of the Don R. Lipsitt award.
Where and when matter in visual recognition.
Our perceptual system processes only a selected subset of an incoming stream of stimuli due to sensory biases and limitations in spatial and temporal attention and working memory capacity. In this study, we investigated perceptual access to sensory information that was temporally predictable or unpredi…
Current and prospective roles of magnetic resonance imaging in mild traumatic brain injury
There is unmet clinical need for biomarkers to predict recovery or the development of long-term sequelae of mild traumatic brain injury, a highly prevalent condition causing a constellation of disabling symptoms. A substantial proportion of patients live with long-lasting sequelae affecting their quality of life and…
Critical components of ‘Early Intervention in Psychosis’: national retrospective cohort study
Background Psychotic disorders are severe mental health conditions frequently associated with long-term disability, reduced quality of life and premature mortality. Early Intervention in Psychosis (EIP) services aim to provide timely, comprehensive packages of care for people with psychotic disorders. Howeve…
Cannabis Withdrawal and Psychiatric Intensive Care.
IMPORTANCE: Cannabis use is common in people with severe mental illness and its adverse effects on outcomes are well established. However, adverse outcomes may also result from cannabis withdrawal syndrome (CWS). CWS includes symptoms such as agitation, irritability, and aggression, and typically p…
Integrating the environmental and genetic architectures of aging and mortality.
Both environmental exposures and genetics are known to play important roles in shaping human aging. Here we aimed to quantify the relative contributions of environment (referred to as the exposome) and genetics to aging and premature mortality. To systematically identify environmental exposures associate…
Adversarial testing of global neuronal workspace and integrated information theories of consciousness.
Different theories explain how subjective experience arises from brain activity1,2. These theories have independently accrued evidence, but have not been directly compared3. Here we present an open science adversarial collaboration directly juxtaposing integrated information theory (IIT)4,5 and global neuro…
Classification of asthma based on nonlinear analysis of breathing pattern
Normal human breathing exhibits complex variability in both respiratory rhythm and volume. Analyzing such nonlinear fluctuations may provide clinically relevant information in patients with complex illnesses such as asthma. We compared the cycle-by-cycle fluctuations of inter-breath interval (IBI) and lung v…
FLUX: A pipeline for MEG analysis.
Magnetoencephalography (MEG) allows for quantifying modulations of human neuronal activity on a millisecond time scale while also making it possible to estimate the location of the underlying neuronal sources. The technique relies heavily on signal processing and source modelling. To this end, there are sev…
Modulation of alpha oscillations by attention is predicted by hemispheric asymmetry of subcortical regions.
Evidence suggests that subcortical structures play a role in high-level cognitive functions such as the allocation of spatial attention. While there is abundant evidence in humans for posterior alpha band oscillations being modulated by spatial attention, little is known about how subcortical regions contribute to th…
Retinal morphological differences in atypical Parkinsonism: A cross-sectional analysis of the AlzEye cohort
Objective: Atypical Parkinsonian syndrome (APS) describes a heterogeneous group of disorders mimicking the clinical presentation of Parkinson disease (PD) but with disparate natural history and pathophysiology. While retinal markers of PD are increasingly described, APS has been afforded less attention possibl…
The long arm of childhood socioeconomic deprivation on mid- to later-life cognitive trajectories: A cross-cohort analysis
AbstractINTRODUCTIONEarlier studies of the effects of childhood socioeconomic status (SES) on later life cognitive function consistently report a social gradient in later life cognitive function. Evidence for their effects on cognitive decline is, however, less clear.METHODSThe sample consists of 5,324 particip…
Evaluating the harmonisation potential of diverse cohort datasets.
Data discovery, the ability to find datasets relevant to an analysis, increases scientific opportunity, improves rigour and accelerates activity. Rapid growth in the depth, breadth, quantity and availability of data provides unprecedented opportunities and challenges for data discovery. A potential tool for increasing…
Semantic Harmonization of Alzheimer's Disease Datasets Using AD-Mapper.
BACKGROUND: Despite numerous past endeavors for the semantic harmonization of Alzheimer's disease (AD) cohort studies, an automatic tool has yet to be developed. OBJECTIVE: As cohort studies form the basis of data-driven analysis, harmonizing them is crucial for cross-cohort analysis. We aimed to acceler…