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Early Adversity & Brain Health
Blossom Early Adversity & Brain Health Programme is dedicated to investigating the effects of early life adversity on later life brain health, including mental health, cognition and dementia.
Heart and Brain Ageing Group
- Alzheimer's
- Brain function
- Brain imaging
- Cognitive
- Dementia
- Magnetic Resonance Imaging (MRI)
- Medical co-morbidity
- Medicine
Nearly a third of dementia cases can be prevented by modifying our lifestyle, in particular our cardiovascular health. While we know that “what’s good for the heart is good for the brain”, we still don’t entirely know why. Our group investigates this heart-brain link in detail, by studying how the health of our heart and large blood vessels affect the brain and memory as we grow older.
Neuroscience, Ethics and Society
- Alzheimer's
- Child development
- Community Mental Health Services
- Neuroscience
- Parenting
- Prevention
- Psychosis
- Schizophrenia
We conduct independent ethics research and we deliver ethical guidance for a range of scientific and clinical studies in the Oxford Department of Psychiatry and Neuroscience. We also work with a variety of international institutions and researchers. Our core research interests involve young people, mental health and neuroscience innovations in a global context.
Translational Neuroscience & Dementia Research
The Translational Neuroscience and Dementia Research Group undertake translational research ranging from mechanisms to drug development, and from discovery to qualification of molecular and imaging biomarkers in both Alzheimer’s disease and Parkinson’s disease and in related dementia disorders. The group, led by Professor Noel Buckley, comprises molecular and cellular biology scientists, computational biologists and informaticians working with molecular, clinical and imaging datasets. We have three main areas of activity, all aiming towards secondary prevention of dementia. By understanding disease mechanisms we seek potential therapeutics; through discovery of biomarkers we hope to enable preventative trials, and with informatics we utilise large biological and clinical datasets in the support of translational neuroscience.
Translational Neuroimaging
- Alzheimer's
- Brain
- Brain function
- Brain imaging
- Clinical trial
- Cognitive models
- Cohorts
- Dementia
- Empirical
- Functional imaging
- Genetics
- Magnetic Resonance Imaging (MRI)
- Medical imaging
- Neuroimaging
- Neurology
- Neuroscience
- Parkinson's
- Risk factors
- Whitehall Study
Neuroimaging provides a window into the living brain, and is an increasingly vital experimental medicine tool for neuro-psychiatric disease. With a particular focus on early and pre-clinical disease, we explore how the brain changes before symptoms take hold.
Neurobiology of Ageing
Why do some people suffer from depression and memory loss as they age, whereas others stay well for the whole of their lives? We examine the effect of genes and life history on ageing using neuropsychology and neuro-imaging techniques as part of large scale epidemiological and experimental medicine studies.