Neuroimaging Analysis for Clinical Translation
- Alzheimer's
- Brain function
- Brain imaging
- Dementia
- Evaluation
- Functional imaging
- Magnetic Resonance Imaging (MRI)
- Medical co-morbidity
- Medical imaging
- Neuroimaging
- Neuroscience
We develop neuroimaging analysis methods that support the translation of brain imaging into clinical practice. We focus on robust, interpretable tools that enable meaningful use of neuroimaging data for understanding, diagnosis, and monitoring of brain disorders.
The Neuroimaging Analysis for Clinical Translation (N-ACT, pronounced “enact”) research group focuses on developing and validating neuroimaging analysis methods intended to support clinical research and translation into clinical practice. The group designs image-analysis tools and workflows that prioritise robustness, interpretability, and reproducibility, with particular emphasis on MRI and related modalities.
N-ACT is part of the NIHR Oxford Health Biomedical Research Centre (OH-BRC), contributing to research in dementia and brain technologies. A central theme of the group’s work is the adaptation of neuroimaging methods developed in large-scale research studies, such as UK Biobank, for use in real-world clinical pathways, including memory-clinic settings. Current projects include integrating MRI research into routine memory-clinic assessments via the Oxford Brain Health Clinic, as well as harmonising imaging measures across sites to ensure more comparable and clinically meaningful imaging data.
Teaching and Training
Members of the N-ACT group are involved in the organisation and delivery of training courses in neuroimaging analysis and clinical translation.
- FSL Course
- OxCIN MRI Graduate Programme
- Oxford Clinical Neuroimaging Course
- MSc in Clinical and Therapeutic Neuroscience (introduction to MRI in the bioassays and biomarkers module; project supervision)
- Software Carpentry workshops (e.g. Python Essentials with Git for Data Analysis)
NEWS
- The Brain Health Clinic received the UK Biobank Scientific Impact Award 2025 for its brain MRI project, presented at the annual UK Biobank conference by Ludovica Griffanti. The work is also featured as a UK Biobank research story.
- Anniversary of the Oxford Brain Health Clinic - 5 years and 500 patients
- 60 Seconds with…. NIHR Oxford Senior Research Fellow Dr Ludovica Griffanti
- Ludovica Griffanti discusses the barriers to adoption study in the NHS for brain magnetic resonance imaging software to support dementia diagnosis in routine clinical practice.
AFFILIATED AND ASSOCIATED GROUPS
Members of the N-ACT group are also part of, or closely linked with, the following research groups and networks: