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Oxford Brain Health Clinic

 The Oxford Brain Heath Clinic (OBHC) is an integrated research and clinical environment. It is dedicated to preparing clinical services for the 21st century to preserve brain health. The clinic was launched in August 2020, as a pilot, to improve the assessment and diagnosis of memory problems. At the clinic, patients are given high-quality assessments not usually available in routine NHS care and are also offered the opportunity to take part in related research.

This page contains information about current and completed research projects. For more information on the clinic, please see the OBHC main page on the NIHR Oxford Health BRC website: https://oxfordhealthbrc.nihr.ac.uk/our-work/brain-health-centre/

Acknowledgments:

The Oxford BHC is a substantial endeavour which has benefitted from many contributors. For details on the contributions of OBHC team members please click here

Research overview:

At the Oxford Brain Health Clinic we offer a comprehensive assessment of brain health at the point of entry into secondary care. This enable investigating what influences health in later life by looking at genetics, lifestyle and health histories. At the same time the data collected represent a baseline for precision recruitment for follow-up studies, clinical trials, and non-pharmacological interventions.At the Oxford Brain Health Clinic we offer a comprehensive assessment of brain health at the point of entry into secondary care. This enable investigating what influences health in later life by looking at genetics, lifestyle and health histories. At the same time the data collected represent a baseline for precision recruitment for follow-up studies, clinical trials, and non-pharmacological interventions.

Publications:

O'Donoghue MC, Blane J, Gillis G, Mitchell R, Lindsay K, Semple J, Pretorius PM, Griffanti L, Fossey J, Raymont V, Martos L, Mackay CE. Oxford brain health clinic: protocol and research database. BMJ Open. 2023 Aug 4;13(8):e067808. doi: 10.1136/bmjopen-2022-067808. PMID: 37541753; PMCID: PMC10407419.

Griffanti L, Gillis G, O'Donoghue MC, Blane J, Pretorius PM, Mitchell R, Aikin N, Lindsay K, Campbell J, Semple J, Alfaro-Almagro F, Smith SM, Miller KL, Martos L, Raymont V, Mackay CE. Adapting UK Biobank imaging for use in a routine memory clinic setting: The Oxford Brain Health Clinic. Neuroimage Clin. 2022;36:103273. doi: 10.1016/j.nicl.2022.103273. Epub 2022 Nov 21. PMID: 36451375; PMCID: PMC9723313.

Preprints:

G Gillis, G Bhalerao, J Blane, R Mitchell, PM Pretorius, C McCracken, ...CE Mackay, L Griffanti. From Big Data to the clinic: methodological and statistical enhancements to implement the UK Biobank imaging framework in a memory clinic. medRxiv, 2024.08. 02.24311402

J Blane, G Gillis, L Griffanti, R Mitchell, PM Pretorius, S Forster, S Shabir, ... CE Mackay. Prevalence of dementia risk factors in a memory clinic setting: The Oxford Brain Health Clinic. medRxiv, 2024.10. 01.24314545

S Sghirripa, G Bhalerao, L Griffanti, G Gillis, CE Mackay, N Voets, S Wong, ...M Jenkinson. Evaluating Traditional, Deep Learning, and Subfield Methods for Automatically Segmenting the Hippocampus from MRI. medRxiv, 2024.08. 06.24311530

L Griffanti, F Serres, L Cini, J Walsh, T Hanayik, U Pervaiz, S Smith, ...M Bajre. Brain magnetic resonance imaging software to support dementia diagnosis in routine clinical practice: a barrier to adoption study in the National Health Service (NHS) England. medRxiv, 2024.08. 02.24311223

GV Bhalerao, G Gillis, M Dembele, S Suri, K Ebmeier, J Klein, M Hu, ... L Griffanti. Automated quality control of T1-weighted brain MRI scans for clinical research: methods comparison and design of a quality prediction classifier. medRxiv, 2024.04. 12.24305603

 

Open Science projects:

  • The MRI protocol used in the OBHC is available in the WIN MR Protocols Database. M Clare O'Donoghue, Jasmine Blane, Juliet Semple, Sebastian Rieger, Nicola Aikin, Jon Campbell, Pieter Pretorius, Ludovica Griffanti, Grace Gillis, Thomas W Okell, Mark Chiew, Stephen M Smith, Karla L Miller, & Clare E Mackay. (2022). WIN MR Protocol: Oxford Brain Health Centre (2019_102_BHC). Zenodo. https://doi.org/10.5281/zenodo.6598036

 

Policy projects:

 

Translation, Innovation and Commercialisation projects:

 

Impact summary 2024OBHC impact summary 2024

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