Department of Psychiatry

Neuroimaging Analysis for Clinical Translation

We develop neuroimaging analysis methods that bridge large-scale population imaging with real-world clinical data, supporting the translation of brain imaging research into clinical practice. We focus on robust, interpretable tools that enable meaningful use of neuroimaging data for understanding, diagnosis, and monitoring of brain disorders.

Autoimmune Psychosis

Translational NeuroStimulation Laboratory

The Translational Neurostimulation Lab (TNSL team) work on understanding neurocognitive mechanisms of brain plasticity in health and neurological/psychiatric disorders. Recent work is focused on advancing non-invasive brain stimulation as a treatment for depression. Using an experimental medicine/cognitive neuroscience approach, we ask mechanistic questions aimed at understanding: How does stimulation work? Who does it work for? How can we make it work better?

Neuroscience, Ethics and Society

We conduct independent ethics research and we deliver ethical guidance for a range of scientific and clinical studies in the Oxford Department of Psychiatry and Neuroscience. We also work with a variety of international institutions and researchers. Our core research interests involve young people, mental health and neuroscience innovations in a global context.

Computational Psychiatry

Using computer models of behaviour, we aim to better understand anxiety and depression, and to guide the development of novel treatments.

Computational and Molecular Neuroscience

The Computational and Molecular Neuroscience Research Group is a multidisciplinary laboratory specialized on the intersection of computational and molecular methods to study neurodegenerative diseases. The computational methods entail mainly Artificial Intelligence and Bioinformatics, while the molecular side brings state of the art multi-culture iPSC models of disease and high throughput screening. We are especially interested in Alzheimer's and Parkinson’s disease, and how we can use the computational and molecular methods mentioned above to find new drug targets and therapies. We have three main areas of activity: better understanding disease to identify new therapies; discovering biomarkers to enable preventative trials; and validating findings in advanced cell models of disease.

Translational Neuroimaging

Neuroimaging provides a window into the living brain, and is an increasingly vital experimental medicine tool for neuro-psychiatric disease. With a particular focus on early and pre-clinical disease, we explore how the brain changes before symptoms take hold.

Psychopharmacology and Emotion Research Laboratory (PERL)

We explore how the brain processes emotional information and how this is influenced by brain chemicals and medicines. This helps us to understand disorders such as depression and anxiety and to understand and contribute to the development of drug and psychological treatments.

Neurobiology and Experimental Therapeutics

We are dedicated to testing and developing new ways of improving treatments for psychiatric disorders, and maintaining brain health during aging. A significant proportion of people suffering from disturbances of mood and memory, do not respond to the available medication, and so there is an urgency to supplement or provide an alternative to current therapies.

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