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NIHR Oxford Health Biomedical Research Centre (BRC)

Brain Brain function Brain imaging Depression Evidence Based Medicine

Oxford Health Biomedical Research Centre aims to create a platform to deliver high quality experimental medicine research on new treatments and procedures to improve lives.

BrainWaves

Brain Child development

BrainWaves is a major response to a growing youth mental health crisis. Our mission is to build the evidence base and resources to power new research and ensure schools become more effective environments for developing wellbeing in young people.

Modifying Dementia Risk

Cognitive Dementia Depression Epidemiology Risk factors

Modifiable risk factors for dementia include those factors that can be altered or changed in some way (modified), usually for the better. The Lancet 2020 commission (Livingston et al., 2020) advocated that there are 12 risk factors which can be potentially modified to prevent or slow the progression of dementia. These are less education, hypertension, obesity, alcohol, traumatic brain injury (TBI), hearing loss, smoking, depression, physical inactivity, social isolation, diabetes and air pollution.

Early Adversity & Brain Health

Alzheimer's Brain function Cognitive Dementia Depression Mood

Blossom Early Adversity & Brain Health Programme is dedicated to investigating the effects of early life adversity on later life brain health, including mental health, cognition and dementia.

Oxford Mental Health Economics and Policy

Decision-making Evaluation

The Oxford Mental Health Economics and Policy research group brings together world-leading researchers in intersection of mental health, economics, and policy across the University of Oxford and it is hosted by the Department of Psychiatry.

EXTEND: Personalised Care for Early Psychosis

The EXTEND: Personalised Care for Early Psychosis study is a multi-centre NIHR-funded study exploring the impact of duration of Early Intervention in Psychosis care on outcomes for individuals experiencing their first episode of psychosis.

Emotional Competence for Well-being (ECoWeB)

The aim of the ECoWeB project is to develop a mobile application (app) called MyMoodCoach to help young people improve their understanding of how emotions work. The app focuses on boosting the skills of recognising, understanding, and managing emotions in young people aged 16-22.

Autoimmune Psychosis

Clinical trial Mental illness Neuroscience Psychosis Randomised trial Research-based Schizophrenia Treatment trials

The CHiMES Collaborative

A Creative Collaborative for Advanced Interdisciplinary Research, Policy & Practice * Underpinned by Methodologies and Critiques from Cultural Psychiatry and Health Inequalities Research * Testing and Evolving Eco-Social, Bio-Psycho-Social, and Syndemic Frameworks

True Colours

Bipolar Depression Mental illness Mood Randomised trial Research-based

A daily and weekly remote symptom monitoring system for patients with over a decade of use in research and clinical service

Heart and Brain Ageing Group

Alzheimer's Brain function Brain imaging Cognitive Dementia Magnetic Resonance Imaging (MRI) Medical co-morbidity Medicine

Nearly a third of dementia cases can be prevented by modifying our lifestyle, in particular our cardiovascular health. While we know that “what’s good for the heart is good for the brain”, we still don’t entirely know why. Our group investigates this heart-brain link in detail, by studying how the health of our heart and large blood vessels affect the brain and memory as we grow older.

MindKind Study: preventing and treating depression and anxiety in young people

We want to understand how best to design a mental health databank which identifies active ingredients in preventing and treating depression and anxiety in young people. We have brought on board young people's voices on how to measure such active ingredients, and how such a databank might be designed, used, and shared. Along with colleagues in Cambridge, we work closely with young people, professionals, and researchers in South Africa and India. We welcome other collaborations and enquiries.

SEEN: Secondary Education around Early Neurodevelopment

In partnership with Kindred Squared, SEEN is a research project to develop and pilot curriculum for Key Stage 3 pupils. It aims to embed the key principles of early child development and neuroscience for young people.

Translational NeuroStimulation Laboratory

Anxiety Behaviour Brain function Brain imaging Cognitive models Decision-making Depression Disorders Evidence based treatment Experimental Functional imaging Information processing Magnetic Resonance Imaging (MRI) Mood Neuroscience Psychological therapy Psychology Therapy

We aim to understand processes of selective attention and action, learning and memory in the human brain. Through experiments in healthy volunteers and patients with brain disorders we seek to characterize how information processing networks respond (adaptively or maladaptively) when challenged by interference. Our motivation is to develop rational neurocognitive intervention strategies to help promote recovery from conditions such as depression and brain injury.

Early Psychosis Research Group

Clinical trial Mental illness Psychosis Schizophrenia Treatment Treatment trials

We undertake research across the translational spectrum, ranging from basis science studies, through to trials of new treatments and approaches for psychosis, right through to researching clinical services and their effectiveness. We work closely with the Oxfordshire Early Intervention in Psychosis Service in Oxford Health NHS FT. This service provides high quality, multi-discliplinary care for people experiencing first episode of psychosis and their families. We also lead the Early Intervention Psychosis network for the NHS in the South of England, providing the opportunity to speed up the translation of new research findings into routine clinical care. You can find out more about our current studies below.

OxWell Student Survey

Our research group runs the OxWell Student Survey, an online school-based study that directly asks students about their mental health, well-being and school experience. Our aim is to learn from school-aged children and adolescents, aged 9-18 years about what they need, which factors influence their wellbeing, and how they would like to access help if they have mental health difficulties. The OxWell 2023 survey (Feb-March 2023) had over 40,000 students participate from 185 schools and Further Education Colleges in 6 local authority areas. Over 200 questions were asked, providing us with invaluable information. The OxWell Survey has previously been conducted in 2021, 2020 and 2019. We work closely with schools, local authorities and mental health commissioners and services and welcome collaborations with interested researchers and services. We would like to thank the schools and students for the considerable time they have spent participating in our study.

Talking to children about serious illness

Talking to children and young people about illness and death is important for their mental health.

Precision Psychiatry

Clinical trial Depression Evidence Based Medicine Mental illness

We are an international multidisciplinary group of researchers, clinicians (both psychiatrists and psychologists), statisticians, methodologists and students who aim to improve the current treatment practice in the NHS and across the world, using innovative approaches from artificial intelligence and machine learning, to digital mental health and bioethics.

U-Flourish: Student Wellbeing Research

We aim to understand and promote mental health and wellbeing for university students.

Oxford Centre for Human Brain Activity Analysis Group

Developing new analysis tools for understanding human brain activity