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If you are interested in hearing about recent advances in Computational Psychiatry, visit the TCPW website!
Clinical Researcher and Honorary Consultant Psychiatrist
I lead the Computational Psychiatry Lab in the Department of Psychiatry.
My research focuses on the role of learning in the aetiology and treatment of the emotional disorders (anxiety and depression).
The emotional disorders are among the most common of the psychiatric illnesses. While there has been significant recent advances in understanding the cognitive and neural systems involved in producing symptoms of both anxiety and depression in response to stressful circumstances or negative life events it is less clear why, when exposed to the same environemnt, some people will become anxious or depressed while others will not. The overall goal of my research is to better understand the mechanisms which lead to this vulnerability and to use this understanding to develop novel, evidence based treatments for these illnesses.
My work combines computational models of cognitive processes with physiological measures of neural function to unpick how patients learn and adapt to their environment. I also use pharamacological and cognitive techniques to modify the abnormal learning which is believed to cause anxiety and depression.
I am a consultant psychiatrist with an honorary contract with Oxford Health NHS Trust. My clinical practice involves the assessment and treatment of patients with mood disorders.
Browning M. et al, (2015), Nat Neurosci, 18, 590 - 596
Browning M. et al, (2012), Biol Psychiatry, 72, 572 - 579
Browning M. and Harmer CJ., (2012), Neuroimage
Clarke PJ. et al, (2014), Biol Psychiatry, 76, 946 - 952
Browning M. et al, (2010), Biol Psychiatry, 67, 919 - 925
Using Computational Psychiatry to Rule Out the Hidden Causes of Depression
pulcu E. and Browning M., (2017), JAMA Psychiatry
Vortioxetine reduces BOLD signal during performance of the N-Back working memory task: A randomised neuroimaging trial in remitted depressed patients and healthy controls.
Harmer CJ. et al, (2017), Molecular Psychiatry
Symptom Trajectories in Discontinuation Trials
Browning M., (2017), The Lancet Psychiatry
Beyond negative valence – two-week administration of a serotonergic antidepressant enhances both reward and effort learning signals
Scholl J. et al, (2017), PLoS Biology
Godlewska BR. et al, (2016), Translational Psychiatry