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Research to look at olfactory stem cells and induced pluripotential stem cells from skin fibroblasts of patients with adolescent-onset schizophrenia and matched healthy controls

Bma margaret temple award 2013 for dr anthony james and colleagues Szele lab unpublished data
Stem cells made nerve cells (white) and support cells (green and red)

Dr James and colleagues Dr Francis Szele (developmental biologist DPAG), Prof Paul Harrison, Mr Nick de Pennington (Neurosurgeon, JR2), Mr Devessa ( ENT surgeon, JR2), Dr S Chance (Research Fellow Clinical Neurology ), Dr Pagnamenta and Dr Taylor (Wellcome Centre Human Genetics) have been awarded  the BMA Margaret Temple  award for 2013. The research is to look at olfactory stem cells and induced pluripotential stem cells from skin fibroblasts of patients with adolescent-onset schizophrenia and matched healthy adolescent controls. For the first time we will be able to directly examine the neurodevelopmental hypothesis of schizophrenia and related epigenetic effects. It is also proposed to look at genetic effects arising during stem cell growth, and by using parental genetic information to examine de novo mutations (DNM), which are now thought to be implicated in some cases of schizophrenia. The work will be carried out in collaboration with Prof Alan Mackay-Sim in Brisbane, a world leader in olfactory stem cell research.