Simon Lovestone
PhD, MRCPsych
Professor of Translational Neuroscience; Senior Fellow in Innovation and Development
I am a clinician scientist working mostly on Alzheimer’s Disease but also on other neurodgeneration disorders such as Parkinson’s disease. Ultimately my group’s research is focussed on trying to find treatments, especially in the early preclinical or prodromal phase of disease. A successful therapy in this phase would delay or prevent symptoms; sometimes referred to as secondary prevention.
With this end in mind my team’s research includes understanding mechanisms and developing novel therapeutic targets, on finding biomarkers to facilitate clinical trials in the early phases of disease and the use of informatics to derive useful information from large datasets, both molecular and clinical.
The lab group’s work is described here and the ARUK Oxford Drug Development Institute led by Lovestone and Bountra is here.
You can find me on Twitter here.
Recent publications
Cerebrospinal fluid proteome alterations related to depressive symptoms in cognitive decline and Alzheimer's disease.
Journal article
Rabl M. et al, (2025), Alzheimers Dement, 21
The evolution of Alzheimer's target identification: Towards a fusion of artificial and cellular intelligence.
Journal article
Wittenberg G. et al, (2025), J Prev Alzheimers Dis, 13
Cerebrospinal fluid proteomic associations of APOE genotypes reveal distinct protective and risk mechanisms for Alzheimer's disease.
Journal article
Vromen EM. et al, (2025), Alzheimers Dement, 21
Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning.
Journal article
Neumann A. et al, (2023), Genome Med, 15
Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment and suspected non-Alzheimer's disease pathophysiology.
Journal article
Delvenne A. et al, (2023), Alzheimers Dement, 19, 807 - 820
