Simon Lovestone
PhD, MRCPsych
Professor of Translational Neuroscience; Senior Fellow in Innovation and Development
I am a clinician scientist working mostly on Alzheimer’s Disease but also on other neurodgeneration disorders such as Parkinson’s disease. Ultimately my group’s research is focussed on trying to find treatments, especially in the early preclinical or prodromal phase of disease. A successful therapy in this phase would delay or prevent symptoms; sometimes referred to as secondary prevention.
With this end in mind my team’s research includes understanding mechanisms and developing novel therapeutic targets, on finding biomarkers to facilitate clinical trials in the early phases of disease and the use of informatics to derive useful information from large datasets, both molecular and clinical.
The lab group’s work is described here and the ARUK Oxford Drug Development Institute led by Lovestone and Bountra is here.
You can find me on Twitter here.
Recent publications
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Identification of a possible proteomic biomarker in Parkinson's disease: discovery and replication in blood, brain and cerebrospinal fluid.
Journal article
Winchester L. et al, (2023), Brain Commun, 5
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New insights into the genetic etiology of Alzheimer's disease and related dementias.
Journal article
Bellenguez C. et al, (2022), Nat Genet, 54, 412 - 436
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Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability.
Journal article
Ng B. et al, (2022), Brain Commun, 4
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Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer′s disease implicate TBCA and TREM2 in disease risk
Journal article
Hillary RF. et al, (2021)
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ANMerge: A comprehensive and accessible Alzheimer’s disease patient-level dataset
Journal article
Birkenbihl C. et al, (2020)
