Incidence and prevalence of asthma, chronic obstructive pulmonary disease and interstitial lung disease between 2004 and 2023: harmonised analyses of longitudinal cohorts across England, Wales, South-East Scotland and Northern Ireland
Whittaker H., Machado AKF., Hatam S., Cook S., Scully S., Evans HTT., Bolton T., Kallis C., Busby J., Heaney LG., Sheikh A., Quint JK., Proudfoot A., Constantine A., Jones D., Rathod K., Ahmed N., Fitzgerald R., O’Connell D., Arafin R., Babu-Narayan S., Karim Z., Shelton J., Slapkova M., Hinchliffe R., Johnson S., Toms R., Townson J., Birney E., Gerstung M., Fitzgerald T., Brown K., Zuckerman B., Wong E., Benton L., Braithwaite T., Webb A., Stevenson A., Jackson A., Sudlow C., Chalmers F., Lewis J., Farrell J., Austin J., Nolan J., Murdock L., Morrice L., Mizani M., Webb M., Forsyth R., Priedon R., Khan S., Petersen S., Bolton T., Welshman Z., Rogers C., Wakefield D., Davies A., Sau A., Kallis C., Ng FS., Tzoulaki I., Quint J., Unwin J., Pastika L., Brodin P., Stone P., Salim S., Cook S., Onida S., Marsland A., Thompson A., Holloway S., Porter T., Denniston A., Mamas M., Douiri A., Oluyase A., Shah A., Dregan A., Ronaldson A., Bone A., Cannata A., Bray B., Wolfe C., Bromage D., Oliver D., Nikiphorou E., Chukwusa E., Williams G., Perera G., Watson H., Marshall I., Higginson I., Martelli JL., Das-Munshi J., Davies J., Downs J., Sleeman K.
Background We describe the epidemiology of asthma, chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) from 2004 to 2023 in England, Wales, Scotland and Northern Ireland (NI) using a harmonised approach. Methods Data from the National Health Service England (NHSE), Clinical Practice Research Datalink Aurum in England, Secure Anonymised Information Linkage Databank in Wales, DataLoch in South-East Scotland and the Honest Broker Service in NI were used. A harmonised approach to COPD, asthma and ILD case definitions, study designs and study populations across the four nations was performed. Age-sex-standardised incidence rates and point prevalence were calculated between 2004 and 2023 depending on data availability. Logistic and negative binomial regression compared incidence and prevalence rates between the start and end of each study period. Linear extrapolation projected incidence rates between 2020 and 2023 to illustrate how observed and projected rates differed. Results Incidence rates were lower in 2019 versus 2005 for asthma (England: incidence rate ratio 0.89, 95% CI 0.88 to 0.90; Wales: 0.66, 0.65 to 0.68; Scotland: 0.67, 0.64 to 0.71; NI: 0.84, 0.81 to 0.86), COPD (England: 0.83, 0.82 to 0.85; Wales: 0.67, 0.65 to 0.69) and higher for ILD (England: 3.27, 3.05 to 3.50; Wales: 1.39, 1.27 to 1.53; Scotland: 1.63, 1.36 to 1.95; NI: 3.03, 2.47 to 3.72). In NHSE, the incidence of asthma was similar in June 2023 versus November 2019, but lower for COPD and higher for ILD. Prevalence of asthma in 2019 in England, Wales, Scotland and NI was 9.7%, 15.9%, 13.2% and 7.0%, respectively, for COPD 4.5%, 5.1%, 4.4% and 3.0%, and for ILD 0.4%, 0.5%, 0.6% and 0.3%. Projected incidence rates were 2.8, 3.4 and 1.8 times lower for asthma, COPD and ILD compared with observed rates at the height of the pandemic. Interpretation Asthma, COPD and ILD affect over 10 million people across the four nations, and a substantial number of diagnoses were missed during the pandemic.