Subcortical volume reduction and cortical thinning 3 months after switching to clozapine in treatment resistant schizophrenia.
Krajner F., Hadaya L., McQueen G., Sendt K-V., Gillespie A., Avila A., Lally J., Hedges EP., Diederen K., Howes OD., Barker GJ., Lythgoe DJ., Kempton MJ., McGuire P., MacCabe JH., Egerton A.
The neurobiological effects of clozapine are under characterised. We examined the effects clozapine treatment on subcortical volume and cortical thickness and investigated whether macrostructural changes were linked to alterations in glutamate or N-acetylaspartate (NAA). Data were acquired in 24 patients with treatment-resistant schizophrenia before and 12 weeks after switching to clozapine. During clozapine treatment we observed reductions in caudate and putamen volume, lateral ventricle enlargement (P