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All cases (86) of Huntington's Disease presenting between 1970 and 1987 in the Grampian Health Board region were identified and a case note analysis of neurological and psychiatric syndromes carried out--the latter using the PSE syndrome check-list. The commonest syndromes were organic impairment, irritability, loss of interest and concentration and simple depression and these were often the presenting psychiatric syndromes. General anxiety, worrying and social unease occurred early, commonly before movement disorder and were associated with longer survival.

Original publication




Journal article


Acta Psychiatr Scand

Publication Date





53 - 60


Anxiety Disorders, Depressive Disorder, Female, Follow-Up Studies, Humans, Huntington Disease, Male, Middle Aged, Neurocognitive Disorders, Neurologic Examination, Retrospective Studies, Social Adjustment, Survival Rate