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OBJECTIVE: This was an investigation of whether treatment with fluoxetine is useful for individuals with bulimia nervosa who do not respond to psychotherapy or relapse afterward. METHOD: Twenty-two patients with bulimia nervosa who had not responded to, or had relapsed following, a course of cognitive behavior therapy or interpersonal psychotherapy were randomly assigned to receive placebo (N=9) or fluoxetine (60 mg/day, N=13) for 8 weeks. RESULTS: The median frequency of binge eating in the previous 28 days declined from 22 to four episodes in the fluoxetine group but increased from 15 to 18 episodes in the placebo group. Similarly, purging frequency in the previous 28 days declined from 30 to six episodes in the fluoxetine group but increased from 15 to 38 episodes in the placebo group. CONCLUSIONS: Fluoxetine may be a useful intervention for patients with bulimia nervosa who have not responded adequately to psychological treatment.

Original publication

DOI

10.1176/appi.ajp.157.8.1332

Type

Journal article

Journal

Am J Psychiatry

Publication Date

08/2000

Volume

157

Pages

1332 - 1334

Keywords

Adult, Bulimia, Cognitive Therapy, Drug Administration Schedule, Female, Fluoxetine, Humans, Placebos, Psychotherapy, Recurrence, Serotonin Uptake Inhibitors, Treatment Outcome