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The prolactin response to intravenous clomipramine, a 5-HT uptake inhibitor, was significantly attenuated in 12 patients with major depression. In contrast, in a further 12 depressed patients, the PRL responses to thyrotropin-releasing hormone, which acts directly on the pituitary to release PRL, were not reduced. These findings suggest that the reduction in 5-HT-mediated PRL release seen in depressed patients is due to an impairment of brain 5-HT function rather than a pituitary abnormality.

Type

Journal article

Journal

Br J Psychiatry

Publication Date

03/1992

Volume

160

Pages

372 - 378

Keywords

Adult, Brain, Clomipramine, Depressive Disorder, Female, Humans, Infusions, Intravenous, Male, Personality Inventory, Prolactin, Receptors, Serotonin, Serotonin, Thyrotropin-Releasing Hormone