Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The addition of lithium to the tricyclic antidepressant medication of 11 depressed patients resulted in an increase in the prolactin response to L-tryptophan after both 4 days and 4 weeks of lithium treatment. There was also a significant fall in Hamilton Depression scores. The results suggest that lithium and tricyclic antidepressants may act synergistically to enhance certain aspects of brain 5-HT function in depressed patients.

Type

Journal article

Journal

Psychopharmacology (Berl)

Publication Date

1989

Volume

99

Pages

230 - 232

Keywords

Adult, Antidepressive Agents, Tricyclic, Depressive Disorder, Drug Resistance, Female, Humans, Lithium, Male, Middle Aged, Neurosecretory Systems, Prolactin, Serotonin, Time Factors, Tryptophan