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The addition of lithium to the tricyclic antidepressant medication of 11 depressed patients resulted in an increase in the prolactin response to L-tryptophan after both 4 days and 4 weeks of lithium treatment. There was also a significant fall in Hamilton Depression scores. The results suggest that lithium and tricyclic antidepressants may act synergistically to enhance certain aspects of brain 5-HT function in depressed patients.


Journal article


Psychopharmacology (Berl)

Publication Date





230 - 232


Adult, Antidepressive Agents, Tricyclic, Depressive Disorder, Drug Resistance, Female, Humans, Lithium, Male, Middle Aged, Neurosecretory Systems, Prolactin, Serotonin, Time Factors, Tryptophan