Lithium increases 5-HT-mediated neuroendocrine responses in tricyclic resistant depression.
Cowen PJ., McCance SL., Cohen PR., Julier DL.
The addition of lithium to the tricyclic antidepressant medication of 11 depressed patients resulted in an increase in the prolactin response to L-tryptophan after both 4 days and 4 weeks of lithium treatment. There was also a significant fall in Hamilton Depression scores. The results suggest that lithium and tricyclic antidepressants may act synergistically to enhance certain aspects of brain 5-HT function in depressed patients.