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Unlike tricyclic antidepressants and monoamine oxidase inhibitors, mianserin did not increase prolactin response to the 5-hydroxytryptamine (5-HT) precursor tryptophan in nine patients with major depression. Antidepressant drugs apparently produce dissimilar effects on this aspect of brain 5-HT function in depressed patients.

Original publication

DOI

10.1176/ajp.145.6.740

Type

Journal article

Journal

Am J Psychiatry

Publication Date

06/1988

Volume

145

Pages

740 - 741

Keywords

Adult, Depressive Disorder, Female, Humans, Male, Mianserin, Middle Aged, Outcome and Process Assessment (Health Care), Prolactin, Psychiatric Status Rating Scales, Serotonin, Tryptophan