Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The pharmacokinetics of L-tryptophan (5 g and 7.5 g) have been studied after its intravenous administration to healthy subjects and the results compared with those obtained after oral administration (0.7 g-3.5 g). In order to do this, we have re-analysed previously published data relating to oral administration. The data obtained following the oral administration of L-tryptophan suggest that the total body clearance and apparent volume of distribution are saturable. The pharmacokinetics of tryptophan after intravenous administration of 5 g and 7.5 g were similar to those after the oral administration of 25 and 50 mg kg-1 (i.e. 1.75 g and 3.5 g). Similar pharmacokinetic values were obtained following intravenous tryptophan when the same subjects were retested after a period of 2-4 weeks.

Type

Journal article

Journal

Br J Clin Pharmacol

Publication Date

10/1985

Volume

20

Pages

317 - 321

Keywords

Administration, Oral, Adult, Humans, Injections, Intravenous, Kinetics, Male, Time Factors, Tryptophan