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The effect on monoamine-medical behaviour of repeated daily subconvulsive doses of the GABA antagonist drugs pentylenetetrazol (PTZ) (30 mg/kg for 8 days), picrotoxin (5 mg/kg for 4 days) and bicuculline (3.5 mg/kg for 16 days) was investigated. None of the drugs, administered chronically, increased behavioural responses to the 5-hydroxytryptamine agonist quipazine (25 mg/kg), and neither picrotoxin nor bicuculline altered the locomotor response to the dopamine agonist apomorphine (AP) (0.1 mg/kg). By contrast, repeated doses of PTZ increased the locomotor response to AP, and also increased circling responses to both AP (0.5 mg/kg) and methamphetamine (2.0 mg/kg) in unilateral nigrostriatal-lesioned rats.

Type

Journal article

Journal

Psychopharmacology (Berl)

Publication Date

1982

Volume

76

Pages

88 - 91

Keywords

Animals, Apomorphine, Behavior, Animal, Bicuculline, GABA Antagonists, Humans, Kindling, Neurologic, Male, Methamphetamine, Motor Activity, Pentylenetetrazole, Picrotoxin, Quipazine, Rats, Rats, Inbred Strains, Receptors, Dopamine, Receptors, Serotonin, Stereotyped Behavior