Multi-state models for investigating possible stages leading to bipolar disorder
Keown-Stoneman CDG., Horrocks J., Darlington GA., Goodday S., Grof P., Duffy A.
Background: It has been proposed that bipolar disorder onsets in a predictable progressive sequence of clinical stages. However, there is some debate in regard to a statistical approach to test this hypothesis. The objective of this paper is to investigate two different analysis strategies to determine the best suited model to assess the longitudinal progression of clinical stages in the development of bipolar disorder.