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Maintenance drug treatment in bipolar disorder is a key component of management. There is clinical uncertainty about the relative efficacy of valproate, either alone or in combination, particularly in comparison to lithium. This month's Cochrane corner review aimed to summarise the best evidence available. This commentary puts the findings into their clinical context and updates them in the light of subsequent analyses and the recent revision of the NICE guidelines on bipolar disorder.

Original publication




Journal article


BJ Psych Advances

Publication Date





3 - 4