Collaborators
Colleges
Chloe Yap
MD PhD GCBusLead BSc
Clinical Researcher
I am an early-career clinician-researcher in psychiatry, working in Professor Philip McGuire's group for the STEP clinical trial.
Unlike any other area of medicine, psychiatry still relies on subjective assessments to fit people into heterogeneous diagnostic categories. While these categories help to guide prognosis and treatment we too often fall short, particularly for people living with severe mental illness.
My research broadly aims to improve diagnosis, prognosis and treatment of severe mental illnesses (e.g., schizophrenia, bipolar disorder). My goal is to find biological markers (biomarkers) that unravel clinical heterogeneity and predict outcomes. I aim to do this by combining my skillset in analysis of large clinical and multi-omic (genomics, epigenomics, metabolomic, metagenomic) datasets with an understanding of clinical heterogeneity.
Prior to joining the University of Oxford, I completed my MD-PhD in 2022 at the University of Queensland, and started psychiatry training in Brisbane with the Royal Australian and New Zealand College of Psychiatrists. My PhD work (supervisors: Prof Jacob Gratten and Prof Naomi Wray) largely involved analysis of the Australian Autism Biobank - a multi-omics dataset with deep clinical phenotyping - and included a stint at UCLA on a Fulbright scholarship. I retain an honorary position with the University of Queensland and Mater Research.