Senior Clinical Research Fellow
I am a clinical academic psychiatrist with a specific interest in early detection and preventive interventions.
I am the clinical lead for OPEN - the Oxford Preventive and Early interventioN service, which seek to help young people 'at risk' of developing severe mental illness, such as psychosis, depression, and bipolar disorder.
My research focuses on clarifying the role of the gut microbiome in the pathophysiology of mental illness and in modulating the efficacy and tolerability of psychotropic medications. I use an inter-disciplinary approach combining clinical, in vitro, and animal models. This is possible thanks to an extended network of collaborators within and beyond the Department of Psychiatry and the University of Oxford.
My overall aim is to develop methods that will support a more personalised approach to
treatment, with the selection of medications informed by each individual’s microbiome
profile, such that they receive the treatment that is most likely to be effective and least likely to cause
Psycho-pharmacomicrobiomics: A Systematic Review and Meta-analysis.
Minichino A. et al, (2023), Biol Psychiatry
Endocannabinoid system mediates the association between gut-microbial diversity and anhedonia/amotivation in a general population cohort.
Minichino A. et al, (2021), Mol Psychiatry, 26, 6269 - 6276
Gut dysbiosis in severe mental illness and chronic fatigue: a novel trans-diagnostic construct? A systematic review and meta-analysis.
Safadi JM. et al, (2022), Mol Psychiatry, 27, 141 - 153