Philip McGuire
Professor of Psychiatry
Philip McGuire is Professor of Psychiatry in the Department of Psychiatry at the University of Oxford. He is Academic Director of SPRINT and a Principle Investigator at the Wellcome Centre for Integrative Neuroimaging. He is co-lead for Precision Psychiatry in the NIHR Oxford Health Biomedical Research Centre and a Consultant Psychiatrist at Oxford Health NHS Foundation Trust.
He studied medicine at the University of Edinburgh and neuroscience at Yale University. He trained as a psychiatrist at the Maudsley Hospital in London, then worked as an academic psychiatrist at the MRC Cyclotron Unit, London and the Institute of Psychiatry in London.
He leads a large research group that aims to understand the mechanisms underlying psychosis and use this information to develop new treatments and improve clinical care. He has published 800 scientific papers, has an h index of 125, and is a Highly Cited Researcher. He is a Fellow of the Academy of Medical Sciences, the Royal College of Psychiatrists, and the European Psychiatric Association.
Recent publications
Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study.
Journal article
Liu S. et al, (2026), Mol Psychiatry, 31, 1707 - 1722
Diazepam modulates anterior cingulate glutamate levels in people at clinical high-risk for psychosis.
Journal article
Kiemes A. et al, (2026), Int J Neuropsychopharmacol, 29
GABAA receptor availability in clinical high-risk and first-episode psychosis: a [11C]Ro15-4513 positron emission tomography study.
Journal article
Lukow PB. et al, (2026), Mol Psychiatry, 31, 987 - 996
Confirmatory factor analysis of competing PANSS negative symptom models: data from OPTiMiSE first-episode schizophrenia study.
Journal article
Demjaha A. et al, (2025), BJPsych Open, 12
Mapping the reciprocal interactions between antidepressants and the gut microbiome: novel targets for the personalisation and optimization of drug response.
Journal article
Liu L. et al, (2025), Mol Psychiatry
