Eighteen schizophrenic patients, 16 patients with idiopathic Parkinson's disease, and the same numbers of age, sex and education matched controls were examined with oddball experiments for the generation of P3. Individual averages were high-pass filtered at different cut-off frequencies with single-pole digital filters with equivalent analogue Butterworth filter profiles. The purpose of this procedure was to simulate analogue high-pass filters used in clinical studies from different centres and to examine their potential effect on group differences. Increasing high-pass filters resulted in a phase lead for all peaks examined (N1, P2, N2, P3). The only group differences were found for P3, which showed a greater phase lead in controls than in the patient groups, usually resulting in a more pronounced group difference. Similar wave forms and filter properties could be modelled by synthetic wave forms consisting of sine waves of different frequencies.

More information
Type

Journal article

Journal

Electroencephalogr Clin Neurophysiol

Publication Date

05/1992

Volume

84

Pages

280 - 287

Keywords

Acoustic Stimulation, Analysis of Variance, Electroencephalography, Evoked Potentials, Humans, Male, Parkinson Disease, Reaction Time, Schizophrenia