The study examines the sensitivity of a region of interest approach to detect functional changes in brain metabolism with SPECT and split-dose 99mTc-exametazime by replicating a simple hand movement experiment previously carried out with PET. Regional uptake of 99mTc-exametazime was determined in 12 healthy controls before and during a thumb-digit opposition task. Analysis of regional uptake was carried out blind to the hand used in the opposition task and showed a significant unilateral activation effect in a pericentral region of interest with opposite results in left- and right-handed activation. The maximum contralateral increase in tracer uptake was 16% before and 26% after correction for back diffusion. This is in good agreement with previous results employing absolute cerebral blood flow determination with PET and confirms the usefulness of 99mTc-exametazime SPECT for the examination of functional metabolic changes.

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Journal article


J Nucl Med

Publication Date





1623 - 1627


Aged, Brain, Cerebrovascular Circulation, Female, Hand, Humans, Male, Middle Aged, Movement, Organotechnetium Compounds, Oximes, Technetium Tc 99m Exametazime, Tomography, Emission-Computed, Tomography, Emission-Computed, Single-Photon