Twenty-five DSM-III-diagnosed schizophrenics and 37 normal and age-matched controls were examined using an oddball paradigm for the generation of P300 and smooth eye-pursuit tasks. Results were compared between groups and related to clinical characteristics, including a family history of psychiatric illness. Group differences were found for P300 amplitudes, latencies and eye-tracking. A family history of psychiatric illness was associated with normal eye-tracking in patients. Small P300 amplitudes alone and in combination with long P300 latencies were associated with a family history in controls.

More information
Type

Journal article

Journal

Acta Psychiatr Scand

Publication Date

10/1990

Volume

82

Pages

283 - 288

Keywords

Adult, Arousal, Attention, Cerebral Cortex, Electroencephalography, Evoked Potentials, Auditory, Evoked Potentials, Somatosensory, Female, Genetic Markers, Humans, Male, Psychiatric Status Rating Scales, Pursuit, Smooth, Risk Factors, Schizophrenia, Schizophrenic Psychology, Signal Processing, Computer-Assisted