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Single photon emission tomography (SPET) with the dopamine D2/3 ligand 123I-IBZM gives a semi-quantitative estimate of dopamine binding. In depressed patients, we predicted evidence of reduced function, i.e. increased binding, particularly in more retarded patients.

More information
Type

Journal article

Journal

Psychol Med

Publication Date

11/1997

Volume

27

Pages

1247 - 1256

Keywords

Adult, Basal Ganglia, Benzamides, Corpus Striatum, Depressive Disorder, Dopamine Antagonists, Female, Functional Laterality, Humans, Male, Middle Aged, Neuropsychological Tests, Psychomotor Performance, Pyrrolidines, Reaction Time, Receptors, Dopamine D2, Sex Factors, Tomography, Emission-Computed, Single-Photon, Up-Regulation, Verbal Behavior