Cardiovascular risk factors and diseases are important etiological factors in depression, particularly late-life depression. Brain changes associated with vascular disease and depression can be detected using magnetic resonance imaging. Using diffusion tensor imaging (DTI), we investigated whether the Framingham Stroke Risk Profile (FSRP), a well-validated risk prediction algorithm, is associated with changes in white-matter connectivity. We hypothesized that depressed participants would show reduced white-matter integrity with higher FSRP, and non-depressed controls (matched for mean vascular risk) would show minimal co-variance with white-matter changes.

More information
Type

Journal article

Journal

Int Psychogeriatr

Publication Date

04/2012

Volume

24

Pages

524 - 531

Keywords

Aged, Algorithms, Brain, Case-Control Studies, Corpus Callosum, Depression, Female, Humans, Interview, Psychological, Magnetic Resonance Imaging, Male, Neuroimaging, Neuropsychological Tests, Psychiatric Status Rating Scales, Risk Assessment, Stroke