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Cardiovascular risk factors and diseases are important etiological factors in depression, particularly late-life depression. Brain changes associated with vascular disease and depression can be detected using magnetic resonance imaging. Using diffusion tensor imaging (DTI), we investigated whether the Framingham Stroke Risk Profile (FSRP), a well-validated risk prediction algorithm, is associated with changes in white-matter connectivity. We hypothesized that depressed participants would show reduced white-matter integrity with higher FSRP, and non-depressed controls (matched for mean vascular risk) would show minimal co-variance with white-matter changes.

More information

Journal article


Int Psychogeriatr

Publication Date





524 - 531


Aged, Algorithms, Brain, Case-Control Studies, Corpus Callosum, Depression, Female, Humans, Interview, Psychological, Magnetic Resonance Imaging, Male, Neuroimaging, Neuropsychological Tests, Psychiatric Status Rating Scales, Risk Assessment, Stroke