Magnetic resonance imaging in late-life depression: multimodal examination of network disruption.
Sexton CE., Allan CL., Le Masurier M., McDermott LM., Kalu UG., Herrmann LL., Mäurer M., Bradley KM., Mackay CE., Ebmeier KP.
Disruption of frontal-subcortical and limbic networks is hypothesized to have a key role in late-life depression (LLD) and can be examined using magnetic resonance imaging (MRI) techniques. Gray matter can be examined using T1-weighted MRI, white matter using T2-weighted MRI and diffusion tensor imaging, and functional connectivity in resting-state networks using functional MRI. Although independent MRI studies have supported gray and white matter abnormalities in frontosubcortical and limbic networks and increased functional connectivity in the default-mode network in depression, no study has concurrently examined gray matter, white matter, and functional connectivity.