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Disruption of frontal-subcortical and limbic networks is hypothesized to have a key role in late-life depression (LLD) and can be examined using magnetic resonance imaging (MRI) techniques. Gray matter can be examined using T1-weighted MRI, white matter using T2-weighted MRI and diffusion tensor imaging, and functional connectivity in resting-state networks using functional MRI. Although independent MRI studies have supported gray and white matter abnormalities in frontosubcortical and limbic networks and increased functional connectivity in the default-mode network in depression, no study has concurrently examined gray matter, white matter, and functional connectivity.

More information
Type

Journal article

Journal

Arch Gen Psychiatry

Publication Date

07/2012

Volume

69

Pages

680 - 689

Keywords

Aged, Aged, 80 and over, Brain, Brain Mapping, Case-Control Studies, Cross-Sectional Studies, Depressive Disorder, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Fibers, Myelinated, Nerve Fibers, Unmyelinated