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Evangeline Foster

Bsc (Hons), MSc


DPhil Student

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I am a DPhil student at the Translational Neurosciences and Dementia Research Group, supervised by Professor  Simon Lovestone and Dr Mene Pangalos (Astra Zeneca). My research focus is furthering the understanding of Clusterin (CLU/ApoJ) in neuronal cells and Alzheimer's disease. 

Currently I am introducing AD-relevant CLU variants into induced pluripotent stem cell (iPSCs) using CRISPR/Cas9 genome editing, to begin to elucidate the mechanisms by which these variants alter AD risk. I also aim to further our understanding of the importance of the nuclear CLU isoform in neuronal cells. To do this I will use a number of cellular assays to identify the effect of CLU variants on the biology and function of CLU, and how this may link to AD risk. 

 

Prior to joining the Lovestone group I completed the MSc Neuroscience course in Oxford as a student at St Edmund Hall. I graduated with a 1st Class (Hons) BSc in Biomedical Science from UCL. 

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