Bsc (Hons), MSc
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I am a final year DPhil student in the Translational Neurosciences and Dementia Research group supervised by Prof. Noel Buckley, Prof. Simon Lovestone and Dr. Mene Pangalos (Astra Zeneca). My research focuses on elucidating the contribution of altered Clusterin protein trafficking to neurodegeneration, with a particular focus on Alzheimer's disease.
Currently, I am using induced pluripotent stem cells and CRISPR/Cas9 to generate iPSCs and iPSC-derived cortical neurons with editions made to the Clusterin gene (CLU) to investigate the functional importance of intracellular clusterin to neuronal phenotype and how alteration of trafficking may influence sensitivity to amyloid-beta.
Prior to joining the Lovestone group I completed the MSc Neuroscience course in Oxford as a student at St Edmund Hall.