Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Henrique Fernandes won the poster prize at the 2014 Brain Prize/FENS meeting in Denmark for "Understanding the neurobiology of early-onset bipolar disorder with psychosis" working in collaboration with Dr Anthony James and Professor Gustavo Deco (Barcelona).

Understanding the neurobiology of  early-onset bipolar disorder with psychosis

Henrique M. Fernandes, Joana Cabral, Mikkel Petersen, Tim J. Van Hartevelt, Anthony C. James, Gustavo Deco & Morten L Kringelbach

Pediatric bipolar disorder (PBD) with psychosis (delusions and/or hallucinations) is currently not well understood in terms of its underlying neurobiology. The diagnosis of PBD is based primarily on taking clinical history, which is considerably more difficult to obtain from children and adolescents than from adults. The clinical diagnosis could potentially benefit from a better understanding of the underlying neurobiology of PBD, and in particular of the early structural changes in connectivity.

In the current study, we examined the changes in structural connectivity and network dynamics between a group of adolescents with PBD and psychosis and a group of healthy controls, having constructed the connectomes using probabilistic tractography and diffusion tensor imaging (DTI). We also investigated the correlations of structural change with several clinical and physiological scores.

We found significant differences in the structural connectivity and nodal efficiency of regions within the so-called ‘default mode’ network, including regions of the medial orbitofrontal cortices, posterior cingulate and medial temporal gyrus. These results also suggest a laterality tendency in the nodal efficiency changes, mainly in areas linked to emotion, visual processing, and word, numbers and face recognition. Further correlation analysis showed that some of those regions, as well as several graph analysis measures, are significantly well correlated with different IQ measures as well as with coding scores.

These results show that the detected changes in the network dynamics are strongly coherent with the well known clinical deficits associated with BPD, mainly in regions involved in brain networks associated with emotional processing and regulation, and cognitive processing. These findings may in time open up new avenues for rebalancing the brain in PBD.


Please follow the link below to read the news on the NIHR BRC website.

Read the news