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Although plasma proteins may serve as markers of neurological disease risk, the molecular mechanisms responsible for inter-individual variation in plasma protein levels are poorly understood. Therefore, we conduct genome- and epigenome-wide association studies on the levels of 92 neurological proteins to identify genetic and epigenetic loci associated with their plasma concentrations (n = 750 healthy older adults). We identify 41 independent genome-wide significant (P 

Original publication




Journal article


Nat Commun

Publication Date





Aged, Biomarkers, Blood Proteins, CpG Islands, DNA Methylation, Epigenesis, Genetic, Female, Genome, Human, Genome-Wide Association Study, Humans, Male, Nervous System Diseases, Quantitative Trait Loci, Scotland