Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936.
Hillary RF., McCartney DL., Harris SE., Stevenson AJ., Seeboth A., Zhang Q., Liewald DC., Evans KL., Ritchie CW., Tucker-Drob EM., Wray NR., McRae AF., Visscher PM., Deary IJ., Marioni RE.
Although plasma proteins may serve as markers of neurological disease risk, the molecular mechanisms responsible for inter-individual variation in plasma protein levels are poorly understood. Therefore, we conduct genome- and epigenome-wide association studies on the levels of 92 neurological proteins to identify genetic and epigenetic loci associated with their plasma concentrations (n = 750 healthy older adults). We identify 41 independent genome-wide significant (P