GWAS on family history of Alzheimer's disease.
Marioni RE., Harris SE., Zhang Q., McRae AF., Hagenaars SP., Hill WD., Davies G., Ritchie CW., Gale CR., Starr JM., Goate AM., Porteous DJ., Yang J., Evans KL., Deary IJ., Wray NR., Visscher PM.
Alzheimer's disease (AD) is a public health priority for the 21st century. Risk reduction currently revolves around lifestyle changes with much research trying to elucidate the biological underpinnings. We show that self-report of parental history of Alzheimer's dementia for case ascertainment in a genome-wide association study of 314,278 participants from UK Biobank (27,696 maternal cases, 14,338 paternal cases) is a valid proxy for an AD genetic study. After meta-analysing with published consortium data (n = 74,046 with 25,580 cases across the discovery and replication analyses), three new AD-associated loci (P