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OBJECTIVE: The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking. METHOD: Within a study that targeted families characterized by a history of smoking, analyses derived a subset of 91 Australian families with two or more offspring with a history of DSM-IV major depressive disorder (affected sibling pairs, N=187) and 25 Finnish families (affected sibling pairs, N=33). Within this affected sibling pairs design, the authors conducted nonparametric linkage analysis. RESULTS: In the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25). CONCLUSIONS: Genome-wide significant linkage was detected for major depressive disorder on chromosome 3p in a sample ascertained for smoking. A linkage peak at this location was also observed in an independent study of major depressive disorder.

Original publication




Journal article


Am J Psychiatry

Publication Date





848 - 852


Adult, Alleles, Chromosomes, Human, Pair 3, Depressive Disorder, Major, Diagnostic and Statistical Manual of Mental Disorders, Diseases in Twins, Finland, Genetic Linkage, Genome-Wide Association Study, Genotype, Humans, Lod Score, Polymorphism, Single Nucleotide, Queensland, Receptors, Metabotropic Glutamate, Smoking