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The 5-HT2 receptor antagonist cyproheptadine significantly increased slow wave sleep in 12 healthy control subjects but not in 12 patients with a history of major depression, maintained on tricyclic antidepressant treatment. Cyproheptadine produced a similar reduction in REM sleep in both groups of subjects. The results are consistent with the hypothesis that tricyclic antidepressant treatment alters brain 5-HT2 receptor sensitivity, but a primary abnormality in slow wave sleep regulation in depressed patients cannot be excluded.


Journal article


J Affect Disord

Publication Date





273 - 277


Adult, Aged, Amitriptyline, Brain, Cyproheptadine, Depressive Disorder, Dothiepin, Double-Blind Method, Electroencephalography, Female, Humans, Male, Middle Aged, Reaction Time, Receptors, Serotonin, Sleep Stages, Sleep, REM