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Pretreatment of nine healthy subjects with the non-selective 5-HT receptor antagonist, metergoline (4 mg), abolished the increase in plasma prolactin produced by the anxiolytic drug, buspirone (15 mg). While these findings are consistent with a role for 5-HT receptors in the stimulatory effect of buspirone on plasma prolactin, a dopaminergic mechanism cannot be excluded by the present data.


Journal article


Psychopharmacology (Berl)

Publication Date





283 - 284


Adult, Buspirone, Ergolines, Female, Humans, Male, Metergoline, Prolactin, Radioimmunoassay