Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

We studied the effect of 3 weeks of moderate calorie restriction on 5-HT-mediated prolactin (PRL) release in healthy volunteers using the 5-HT-releasing agent d-fenfluramine. In women, dieting significantly lowered plasma total and free tryptophan (TRP) and increased the PRL response to d-fenfluramine. None of these measures were altered in men who dieted. These findings add to the data indicating that dieting alters brain 5-HT function in women, perhaps as a consequence of reducing the availability of plasma TRP.

Type

Journal article

Journal

J Affect Disord

Publication Date

21/02/1995

Volume

33

Pages

89 - 97

Keywords

Adult, Analysis of Variance, Brain, Diet, Reducing, Female, Fenfluramine, Humans, Male, Prolactin, Reproducibility of Results, Serotonin, Sex Characteristics, Tryptophan