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In recent years new methodologies for developing treatment recommendations that give consideration to evidence, values, preferences and feasibility issues have been developed. One of the most well-developed approaches is the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. This article briefly presents how this methodology may be employed to develop treatment recommendations that might constitute a permanent infrastructure between primary research and everyday clinical practice.


Journal article


Epidemiol Psychiatr Sci

Publication Date





29 - 31


Cross-Sectional Studies, Evidence-Based Medicine, Feasibility Studies, Humans, Italy, Mental Disorders, Practice Guidelines as Topic, Quality Assurance, Health Care, Randomized Controlled Trials as Topic