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Tau was originally isolated from brain microtubules and shown to be a microtubule-associated protein (MAP) that promoted tubulin polymerization (1). It is largely confined to axons, where it is the major MAP. It promotes microtubule nucleation, elongation, and bundling, and stabilizes microtubules by inhibiting depolymerization.

Original publication

DOI

10.1385/1-59259-195-7:375

Type

Journal article

Journal

Methods Mol Med

Publication Date

2000

Volume

32

Pages

375 - 393