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Autoradiographic localization of 5'-N-ethylcarboxamido[3H]adenosine ([3H]NECA) binding sites revealed a heterogeneous labeling of guinea-pig intestine with heavy labeling over the enteric ganglia and in clusters over the mucosa; a low level of label was homogeneously distributed over the muscularis externa. Under the conditions employed, no binding sites were revealed using [3H]-N6-cyclohexyladenosine ([3H]CHA), although both [3H]CHA and [3H]NECA binding sites were localized over comparable areas of rat brain. The relationship of the [3H]NECA binding sites to extracellular adenosine receptors is discussed.

Type

Journal article

Journal

Brain Res

Publication Date

20/06/1983

Volume

269

Pages

374 - 377

Keywords

2-Chloroadenosine, Adenosine, Adenosine-5'-(N-ethylcarboxamide), Animals, Binding Sites, Brain, Cecum, Guinea Pigs, Ileum, In Vitro Techniques, Intestinal Mucosa, Myenteric Plexus, Receptors, Cell Surface, Receptors, Purinergic