I am a postdoctoral researcher within the Translational Neuroscience and Dementia Research group. My research interests are in using stem-cell derived neural cells including neurons, astrocytes and microglia, to create better models of Alzheimer’s disease to improve our understanding of disease mechanisms and identify and screen new therapeutic targets.
I am currently involved in projects investigating how a vast array of clinical measures from patients with Alzheimer’s disease can be recapitulated using the patient’s own cells, and how artificial intelligence approaches can be used to distinguish the phenotypic signature of stem-cell derived neural cells containing risk genes for Alzheimer’s disease.
Inhibition of insulin-degrading enzyme in human neurons promotes amyloid-β deposition
Rowland HA. et al, (2023), Neuronal Signaling
Deep learning-based cell profiling based on neuronal morphology
Liu Q. et al, (2023)
iPSC-Astrocyte morphology reflects patient clinical markers
Rowland HA. et al, (2023)
Temporal transcriptional control of neural induction in human induced pluripotent stem cells.
Gupta S. et al, (2023), Front Mol Neurosci, 16
Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability.
Ng B. et al, (2022), Brain Commun, 4