Jacinta O'Shea
Jacinta O'Shea
DPhil, MSc, MA, BA
Professor of Cognitive Neuroscience | Wellcome/Royal Society Sir Henry Dale Fellow
Manipulating brain plasticity for therapeutic gain
I am a cognitive neuroscientist interested in cognition, action and neurobehavioural plasticity. In our group we use neural interference methods, combined with neuroimaging and detailed cognitive and behavioural probes, to make reverse inference about how information processing is organised in the healthy brain. We aim to leverage these insights within an experimental medicine framework to develop novel therapeutics to aid individuals affected by psychiatric or neurological conditions. For more information see our research group website.
Google scholar link: https://scholar.google.co.uk/citations?hl=en&user=BD8dNTUAAAAJ
Key publications
The effect of pulse shape in theta-burst stimulation: Monophasic vs biphasic TMS.
Journal article
Wendt K. et al, (2023), Brain Stimul, 16, 1178 - 1185
Age-related decline in cortical inhibitory tone strengthens motor memory.
Journal article
Petitet P. et al, (2021), Neuroimage, 245
Effect of Prefrontal Cortex Stimulation on Regulation of Amygdala Response to Threat in Individuals With Trait Anxiety: A Randomized Clinical Trial.
Journal article
Ironside M. et al, (2019), JAMA Psychiatry, 76, 71 - 78
Induced sensorimotor cortex plasticity remediates chronic treatment-resistant visual neglect.
Journal article
O'Shea J. et al, (2017), Elife, 6
Predicting behavioural response to TDCS in chronic motor stroke.
Journal article
O'Shea J. et al, (2014), Neuroimage, 85 Pt 3, 924 - 933
Recent publications
Chronicity moderates the impact of severity on central executive-default mode network functional interactions in depression.
Journal article
Zanao T. et al, (2026), Sci Rep
Positive bias in brain and behaviour as a mechanism of transcranial magnetic stimulation depression treatment.
Journal article
Sarrazin V. et al, (2026), Mol Psychiatry
ntidepressant effects of intermittent theta-burst stimulation are associated with lower baseline regional gray matter volumes and surface areas in prefrontal cortex.
Journal article
Cavendish BA. et al, (2026), J Psychiatr Res, 193, 179 - 187
Chronicity moderates the impact of severity on Central Executive - Default Mode Network functional interactions in Depression
Preprint
Zanao T. et al, (2026)
Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines (2017-2025: An update) - endorsed by the European Society for Brain Stimulation (ESBS) and by the International Federation for Clinical Neurophysiology (IFCN).
Journal article
Antal A. et al, (2025), Clin Neurophysiol
