BSc., Dipl. Psych., Dr.
I am a postdoctoral researcher in the Cognitive Computational Neuroscience (CCN) lab, headed by Laurence Hunt. In my work, I try to understand how we learn and make decisions in a dynamic, uncertain environment. To that end, I combine computational models with measures of behaviour and brain function. I believe in transparent, reproducible, and inclusive science.
In my current projects, I (1) study how we flexibly adapt our learning and decision-making strategies to different levels of stability and noise in our environment, (2) develop novel paradigms that allow us to measure the neural signatures of this flexibility in a fast, yet reliable way using EEG and MEG, and (3) test how the drug ketamine affects this flexibility in different domains (sensory, reward, emotion, interoception). I am intrigued by the dual role of ketamine in psychiatry, as a pharmacological model of psychosis on the one hand, and a rapid antidepressant on the other hand.
Prior to coming to Oxford, I completed my PhD in Translational Neuromodeling with Klaas Enno Stephan and Frederike Petzschner at the ETH Zurich in Switzerland. There, I used hierarchical Bayesian models, pharmacology, and EEG to understand how we process sensory signals in the auditory domain (using mismatch negativity paradigms) and in the interoceptive domain (using heartbeat evoked potential paradigms). My background is in psychology (German diploma/MSc) and physics (BSc), both of which I studied at the Philipps University Marburg in Germany.
Decision-making in dynamic, continuously evolving environments: quantifying the flexibility of human choice
Ruesseler M. et al, (2022)
Auditory mismatch responses are differentially sensitive to changes in muscarinic acetylcholine versus dopamine receptor function
Weber LA. et al, (2022), eLife, 11
A Developmental Framework for Embodiment Research: The Next Step Toward Integrating Concepts and Methods.
Lux V. et al, (2021), Front Syst Neurosci, 15
TAPAS: An Open-Source Software Package for Translational Neuromodeling and Computational Psychiatry.
Frässle S. et al, (2021), Front Psychiatry, 12
Ketamine Affects Prediction Errors about Statistical Regularities: A Computational Single-Trial Analysis of the Mismatch Negativity
Weber LA. et al, (2020), The Journal of Neuroscience, 40, 5658 - 5668