Research groups
William Sproviero
PhD
Oxford-Janssen Human Genomics Fellow
- Bioinformatician
Genetics of Dementia
I am part of the informatics team working on dementia and Alzheimer's Disease in the Translational Neuroscience and Dementia Research Group. I am a bioinformatician and a geneticist, and my main focus is to use large genetic datasets to better understanding the impact of genetic variants on Dementia onset and disease heterogeneity across patients. This requires the use of both classical common and rare genome-wide analyses, as well as, the application of more advanced machine learning methodologies, able to capture phenotypic and genetic differences in the same population cohort.
Recent publications
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Interplay of Metabolome and Gut Microbiome in Individuals With Major Depressive Disorder vs Control Individuals.
Journal article
Amin N. et al, (2023), JAMA Psychiatry, 80, 597 - 609
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Integrating the environmental and genetic architectures of mortality and aging
Preprint
Argentieri A. et al, (2023)
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Interplay of the human exposome, metabolome and gut microbiome in dementia and major depression
Conference paper
van Duijn CM. et al, (2022), Alzheimer's and Dementia, 18
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Comparative effect of metformin versus sulfonylureas with dementia and Parkinson's disease risk in US patients over 50 with type 2 diabetes mellitus.
Journal article
Newby D. et al, (2022), BMJ Open Diabetes Res Care, 10
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The relationship between isolated hypertension with brain volumes in UK Biobank.
Journal article
Newby D. et al, (2022), Brain Behav, 12