Oxford-Janssen Human Genomics Fellow
Genetics of Dementia
I am part of the informatics team working on dementia and Alzheimer's Disease in the Translational Neuroscience and Dementia Research Group. I am a bioinformatician and a geneticist, and my main focus is to use large genetic datasets to better understanding the impact of genetic variants on Dementia onset and disease heterogeneity across patients. This requires the use of both classical common and rare genome-wide analyses, as well as, the application of more advanced machine learning methodologies, able to capture phenotypic and genetic differences in the same population cohort.
High Blood Pressure and Risk of Dementia: a Two-Sample Mendelian Randomization study in the UK Biobank
SPROVIERO W. et al, (2020), Biological Psychiatry
Genome-wide Meta-analysis Finds the ACSL5-ZDHHC6 Locus Is Associated with ALS and Links Weight Loss to the Disease Genetics.
Iacoangeli A. et al, (2020), Cell Rep, 33
ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization.
Tazelaar GHP. et al, (2020), Brain Commun, 2
Opioid use, post-operative complications, and implant survival after unicompartmental versus total knee replacement_ a population-based network study
Burn E. et al, (2019), Lancet Rheumatology
C9orf72 intermediate expansions of 24-30 repeats are associated with ALS.
Iacoangeli A. et al, (2019), Acta Neuropathol Commun, 7